human SCN1B Over-expression AAV

Cat. No: AAV-222367

Availability: 3-5 weeks

Name: AAV-h-SCN1B

This is an AAV expressing Human SCN1B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SCN1B
Gene Name: sodium voltage-gated channel beta subunit 1
Gene ID: 6324
Gene Synonyms: ATFB13; BRGDA5; GEFSP1
ORF Size: 657 bp
RefSeq#: BC112922
Gene Description: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.436646
HGNC ID: HGNC:10586