human RTN3 Over-expression AAV

Cat. No: AAV-222089

Availability: 3-5 weeks

Name: AAV-h-RTN3

This is an AAV expressing Human RTN3.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RTN3
Gene Name: reticulon 3
Gene ID: 10313
Gene Synonyms: ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
ORF Size: 3039 bp
RefSeq#: BC148632
Gene Description: RTN3 belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
UniGene ID: Hs.473761
HGNC ID: HGNC:10469