human RRM1 Over-expression AAV

Cat. No: AAV-222002

Availability: 3-5 weeks

Name: AAV-h-RRM1

This is an AAV expressing Human RRM1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RRM1
Gene Name: ribonucleotide reductase catalytic subunit M1
Gene ID: 6240
Gene Synonyms: R1; RIR1; RR1
ORF Size: 2379 bp
RefSeq#: BC006498
Gene Description: RRM1 encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. RRM1 may play a role in malignancies and disease that involve this region.
UniGene ID: Hs.445705
HGNC ID: HGNC:10451