human PLP1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-219222
Availability:
3-5 weeks
Name:
AAV-h-PLP1
This is an AAV expressing Human PLP1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- PLP1
- Gene Name
- proteolipid protein 1
- Gene ID
- 5354
- Gene Synonyms
- GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; SPG2
- ORF Size
- 729 bp
- RefSeq#
- BC002665
- Gene Description
- PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
- UniGene ID
- Hs.1787
- HGNC ID
- HGNC:9086
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