human KREMEN2 Over-expression AAV

Cat. No: AAV-213365

Availability: 3-5 weeks

Name: AAV-h-KREMEN2

This is an AAV expressing Human KREMEN2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: KREMEN2
Gene Name: kringle containing transmembrane protein 2
Gene ID: 79412
Gene Synonyms: KRM2
ORF Size: 1263 bp
RefSeq#: BC003533
Gene Description: KREMEN2 encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
UniGene ID: Hs.661128
HGNC ID: HGNC:18797