human GRB10 Over-expression AAV

Cat. No: AAV-210487

Availability: 3-5 weeks

Name: AAV-h-GRB10

This is an AAV expressing Human GRB10.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GRB10
Gene Name: growth factor receptor bound protein 10
Gene ID: 2887
Gene Synonyms: Grb-10; GRB-IR; IRBP; MEG1; RSS
ORF Size: 1611 bp
RefSeq#: BC024285
Gene Description: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified.
UniGene ID: Hs.164060
HGNC ID: HGNC:4564