human FGFR3 Over-expression AAV

Name 
AAV-h-FGFR3
Cat No 
AAV-208996
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human FGFR3.

AAV-208996
AAV-h-FGFR3

Ready-to-use AAV expressing Human FGFR3 (fibroblast growth factor receptor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ACH; CD333; CEK2; HSFGFR3EX; JTK4
Description (Vector)
FGFR3 encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
Gene ID
2261
Gene Name (Vector)
fibroblast growth factor receptor 3
Gene Symbol
FGFR3
HGNC ID
HGNC:3690
ORF Size (aa)
2421
ORF Size (bp)
2421 bp
RefSeq ID
NM_000142
RefSeq Synonyms
NM_022965, NM_001163213, NM_000142, BC166684,
Species
human
UniGene ID
Hs.1420

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.