human DENND1B Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-206866
Availability:
3-5 weeks
Name:
AAV-h-DENND1B
This is an AAV expressing Human DENND1B.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- DENND1B
- Gene Name
- DENN domain containing 1B
- Gene ID
- 163486
- Gene Synonyms
- C1ORF18; C1orf218; FAM31B
- ORF Size
- 1191 bp
- RefSeq#
- BC022561
- Gene Description
- Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 (PubMed 20154091)).(supplied by OMIM, Nov 2010)
- UniGene ID
- Hs.657779
- HGNC ID
- HGNC:28404
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