human SERF1A Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-222634
Availability:
3-5 weeks
Name:
AAV-h-SERF1A
This is an AAV expressing Human SERF1A.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- SERF1A
- Gene Name
- small EDRK-rich factor 1A
- Gene ID
- 8293
- Gene Synonyms
- 4F5; FAM2A; H4F5; SERF1; SMAM1
- ORF Size
- 333 bp
- RefSeq#
- BC035932
- Gene Description
- SERF1A is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene.
- UniGene ID
- Hs.559428
- HGNC ID
- HGNC:10755
Related Products
Product | Cat No. |
---|---|
AAV-h-SERF1A | AAV-222636 |
Ad-h-SERF1A | ADV-222634 |
Ad-h-SERF1A | ADV-222636 |
AAV-h-SERF1A-shRNA | shAAV-222636 |
Ad-h-SERF1A-shRNA | shADV-222636 |
Control Products
Vector Biolabs
293 Great Valley Parkway
Malvern, PA 19355
Email: info@vectorbiolabs.com
Phone: +1 484-325-5100
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Fax: +1 215-525-1112
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