rat SFRS10 shRNA silencing AAV

Cat. No: shAAV-292121

Availability: 4-5 weeks

Name: AAV-r-SFRS10-shRNA

This is an AAV expressing shRNA for silencing of Rat Tra2b.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Tra2b
Gene Name: transformer 2 beta homolog (Drosophila)
Gene ID: 117259
Gene Synonyms: Sfrs10; Srsf10
ORF Size: 867 bp
RefSeq#: NM_057119
Gene Description: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.