human HAP1 shRNA silencing AAV

Cat. No: shAAV-210778

Availability: 6-8 weeks

Name: AAV-h-HAP1-shRNA

This is an AAV expressing shRNA for silencing of Human HAP1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HAP1
Gene Name: huntingtin associated protein 1
Gene ID: 9001
Gene Synonyms: HAP2; hHLP1; HIP5; HLP
ORF Size: 2016 bp
RefSeq#: NM_001079870
Gene Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniGene ID: Hs.158300
HGNC ID: HGNC:4812