human NBL1 shRNA silencing AAV

Cat. No: shAAV-216363

Availability: 6-8 weeks

Name: AAV-h-NBL1-shRNA

This is an AAV expressing shRNA for silencing of Human NBL1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NBL1
Gene Name: neuroblastoma 1, DAN family BMP antagonist
Gene ID: 4681
Gene Synonyms: D1S1733E; DAN; DAND1; NB; NO3
ORF Size: 543 bp
RefSeq#: NM_005380
Gene Description: NBL1 product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been observed.
UniGene ID: Hs.654502
HGNC ID: HGNC:7650