human PYCARD shRNA silencing AAV

Cat. No: shAAV-220439

Availability: 6-8 weeks

Name: AAV-h-PYCARD-shRNA

This is an AAV expressing shRNA for silencing of Human PYCARD.

Request a Quote

Please enter your email address and we'll be in touch with more information:

Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PYCARD
Gene Name: PYD and CARD domain containing
Gene ID: 29108
Gene Synonyms: ASC; CARD5; TMS; TMS-1; TMS1
ORF Size: 408 bp
RefSeq#: NM_013258
Gene Description: PYCARD encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.499094
HGNC ID: HGNC:16608