mouse SCG5 shRNA silencing AAV

Cat. No: shAAV-271427

Availability: 6-8 weeks

Name: AAV-m-SCG5-shRNA

This is an AAV expressing shRNA for silencing of Mouse Scg5.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Scg5
Gene Name: secretogranin V
Gene ID: 20394
Gene Synonyms: 7B2; AI325031; Sgne-1; Sgne1
ORF Size: 639 bp
RefSeq#: NM_009162
Gene Description: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
UniGene ID: Mm.4836