human HAMP shRNA silencing AAV

Cat. No: shAAV-210772

Availability: 6-8 weeks

Name: AAV-h-HAMP-shRNA

This is an AAV expressing shRNA for silencing of Human HAMP.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HAMP
Gene Name: hepcidin antimicrobial peptide
Gene ID: 57817
Gene Synonyms: HEPC; HFE2B; LEAP1; PLTR
ORF Size: 255 bp
RefSeq#: NM_021175
Gene Description: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
UniGene ID: Hs.8821
HGNC ID: HGNC:15598