human DDC shRNA silencing AAV

Cat. No: shAAV-206697

Availability: 4-5 weeks

Name: AAV-h-DDC-shRNA

This is an AAV expressing shRNA for silencing of Human DDC.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: DDC
Gene Name: dopa decarboxylase
Gene ID: 1644
Gene Synonyms: AADC
ORF Size: 1443 bp
RefSeq#: NM_000790
Gene Description: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
UniGene ID: Hs.359698
HGNC ID: HGNC:2719