human TNFRSF9 shRNA silencing AAV

Cat. No: shAAV-226095

Availability: 6-8 weeks

Name: AAV-h-TNFRSF9-shRNA

This is an AAV expressing shRNA for silencing of Human TNFRSF9.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TNFRSF9
Gene Name: TNF receptor superfamily member 9
Gene ID: 3604
Gene Synonyms: 4-1BB; CD137; CDw137; ILA
ORF Size: 768 bp
RefSeq#: NM_001561
Gene Description: TNFRSF9 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
UniGene ID: Hs.654459
HGNC ID: HGNC:11924