mouse MAS1 shRNA silencing AAV

Cat. No: shAAV-264280

Availability: 6-8 weeks

Name: AAV-m-MAS1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Mas1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Mas1
Gene Name: MAS1 oncogene
Gene ID: 17171
Gene Synonyms: Mas-1; Mgra
ORF Size: 975 bp
RefSeq#: NM_008552
Gene Description: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
UniGene ID: Mm.425994