human UBE2D1 shRNA silencing AAV

Cat. No: shAAV-226996

Availability: 4-5 weeks

Name: AAV-h-UBE2D1-shRNA

This is an AAV expressing shRNA for silencing of Human UBE2D1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: UBE2D1
Gene Name: ubiquitin conjugating enzyme E2 D1
Gene ID: 7321
Gene Synonyms: E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
ORF Size: 444 bp
RefSeq#: NM_003338
Gene Description: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.129683
HGNC ID: HGNC:12474