mouse WRAP53 shRNA silencing AAV

Cat. No: shAAV-276336

Availability: 4-5 weeks

Name: AAV-m-WRAP53-shRNA

This is an AAV expressing shRNA for silencing of Mouse Wrap53.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Wrap53
Gene Name: WD repeat containing, antisense to Trp53
Gene ID: 216853
Gene Synonyms: BC021790; Wdr79
ORF Size: 1599 bp
RefSeq#: NM_144824
Gene Description: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.
UniGene ID: Mm.31586