human UGT1A4 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-232216
Availability:
6-8 weeks
Name:
AAV-h-UGT1A4-shRNA
This is an AAV expressing shRNA for silencing of Human UGT1A4.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- UGT1A4
- Gene Name
- UDP glucuronosyltransferase family 1 member A4
- Gene ID
- 54657
- Gene Synonyms
- HUG-BR2; UDPGT; UDPGT 1-4; UGT-1D; UGT1-04; UGT1.4; UGT1A4S; UGT1D
- ORF Size
- 1338 bp
- RefSeq#
- NM_007120
- Gene Description
- UGT1A4 encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A4 is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
- UniGene ID
- Hs.
- HGNC ID
- HGNC:12536
Related Products
Product | Cat No. |
---|---|
AAV-h-UGT1A4 | AAV-231512 |
AAV-h-UGT1A4 | AAV-232216 |
Ad-h-UGT1A4 | ADV-231512 |
Ad-h-UGT1A4 | ADV-232216 |
Ad-h-UGT1A4-shRNA | shADV-232216 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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