human PROC shRNA silencing AAV

Cat. No: shAAV-219921

Availability: 6-8 weeks

Name: AAV-h-PROC-shRNA

This is an AAV expressing shRNA for silencing of Human PROC.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PROC
Gene Name: protein C, inactivator of coagulation factors Va and VIIIa
Gene ID: 5624
Gene Synonyms: APC; PC; PROC1; THPH3; THPH4
ORF Size: 1386 bp
RefSeq#: NM_000312
Gene Description: PROC encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
UniGene ID: Hs.224698
HGNC ID: HGNC:9451