mouse RBPMS shRNA silencing AAV

Cat. No: shAAV-270298

Availability: 6-8 weeks

Name: AAV-m-RBPMS-shRNA

This is an AAV expressing shRNA for silencing of Mouse Rbpms.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Rbpms
Gene Name: RNA binding protein gene with multiple splicing
Gene ID: 19663
Gene Synonyms: 2010300K22Rik; 2700019M19Rik; AU017537; hermes; RBP-MS
ORF Size: 594 bp
RefSeq#: NM_019733
Gene Description: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.
UniGene ID: Mm.323997