mouse GPR120 shRNA silencing AAV

Cat. No: shAAV-260561

Availability: 6-8 weeks

Name: AAV-m-GPR120-shRNA

This is an AAV expressing shRNA for silencing of Mouse Ffar4.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Ffar4
Gene Name: free fatty acid receptor 4
Gene ID: 107221
Gene Synonyms: AI552415; Gpr120; Gpr129; GT01; KPG_013; O3far1; Pgr4
ORF Size: 1086 bp
RefSeq#: NM_181748
Gene Description: Receptor for medium and long-chain free fatty acid (FAA). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1 dependent effect but independent of G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediates the taste of fatty acids (By similarity).
UniGene ID: Mm.35288