human TIE1 shRNA silencing AAV

Cat. No: shAAV-225495

Availability: 4-5 weeks

Name: AAV-h-TIE1-shRNA

This is an AAV expressing shRNA for silencing of Human TIE1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TIE1
Gene Name: tyrosine kinase with immunoglobulin like and EGF like domains 1
Gene ID: 7075
Gene Synonyms: JTK14; TIE
ORF Size: 3417 bp
RefSeq#: NM_005424
Gene Description: TIE1 encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniGene ID: Hs.78824
HGNC ID: HGNC:11809