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human TIE1 shRNA silencing Adenovirus

Name 
Ad-h-TIE1-shRNA
Cat No 
shADV-225495
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human TIE1.

shADV-225495
Ad-h-TIE1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
JTK14; TIE
Description (Vector)
TIE1 encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
7075
Gene Name (Vector)
tyrosine kinase with immunoglobulin like and EGF like domains 1
Gene Symbol
TIE1
HGNC ID
HGNC:11809
ORF Size (aa)
3417
ORF Size (bp)
3417 bp
RefSeq ID
NM_005424
RefSeq Synonyms
NM_005424, NM_001253357, BC038239,
Species
human
UniGene ID
Hs.78824

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.