mouse LEPR shRNA silencing Adenovirus

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Mouse

Gene Symbol

Lepr

Gene Name

leptin receptor

Gene ID

16847

Gene Synonyms

db; diabetes; Leprb; LEPROT; Modb1; OB-RGRP; obese-like; obl; Obr

ORF Size

2457 bp

RefSeq#

NM_010704

Gene Description

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).

UniGene ID

Mm.259282