human SUFU shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

SUFU

Gene Name

SUFU negative regulator of hedgehog signaling

Gene ID

51684

Gene Synonyms

PRO1280; SUFUH; SUFUXL

ORF Size

1455 bp

RefSeq#

NM_016169

Gene Description

The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.

UniGene ID

Hs.404089

HGNC ID

HGNC:16466