human PPM1E shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PPM1E

Gene Name

protein phosphatase, Mg2+/Mn2+ dependent 1E

Gene ID

22843

Gene Synonyms

caMKN; CaMKP-N; POPX1; PP2CH

ORF Size

2274 bp

RefSeq#

NM_014906

Gene Description

PPM1E encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.

UniGene ID

Hs.245044

HGNC ID

HGNC:19322