human RGS5 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

RGS5

Gene Name

regulator of G-protein signaling 5

Gene ID

8490

Gene Synonyms

MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129

ORF Size

546 bp

RefSeq#

NM_003617

Gene Description

RGS5 encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. RGS5 is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. RGS5 is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified.

UniGene ID

Hs.24950

HGNC ID

HGNC:10001