mouse 2400001E08RIK Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-250719
Availability:
3-5 weeks
Name:
AAV-m-2400001E08RIK
This is an AAV expressing Mouse Lamtor1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Lamtor1
- Gene Name
- late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
- Gene ID
- 66508
- Gene Synonyms
- 2400001E08Rik; p18; Pdro
- ORF Size
- 486 bp
- RefSeq#
- BC126973
- Gene Description
- Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
- UniGene ID
- Mm.359278
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