human LEF1 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-213813
Availability:
3-5 weeks
Name:
AAV-h-LEF1
This is an AAV expressing Human LEF1.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- LEF1
- Gene Name
- lymphoid enhancer binding factor 1
- Gene ID
- 51176
- Gene Synonyms
- LEF-1; TCF10; TCF1ALPHA; TCF7L3
- ORF Size
- 1200 bp
- RefSeq#
- BC050632
- Gene Description
- LEF1 encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. LEF1 has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
- UniGene ID
- Hs.555947
- HGNC ID
- HGNC:6551
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