mouse EXO1 shRNA silencing Adenovirus

Name
Ad-m-EXO1-shRNA

Cat No
shADV-258767

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Exo1.

shADV-258767

Ad-m-EXO1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Exo1 (exonuclease 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

5730442G03Rik; Msa

Description (Vector)

5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.

Gene ID

26909

Gene Name (Vector)

exonuclease 1

Gene Symbol

Exo1

ORF Size (aa)

2514

ORF Size (bp)

2514 bp

RefSeq ID

NM_012012

RefSeq Synonyms

NM_012012, BC006671,

Species

mouse

UniGene ID

Mm.283046

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.