human RAB3GAP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human RAB3GAP1.
shADV-220552
Ad-h-RAB3GAP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human RAB3GAP1 (RAB3 GTPase activating protein catalytic subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
P130; RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa subunit; rab3 GTPase-activating protein catalytic subunit; RAB3GAP; Rab3-GAP; rab3-GAP p130; RAB3GAP130; WARBM1
Description (eCommerce)
Rab3-GAP1 is the catalytic subunit of Rab3-GAP. Rab3-GAP is a key regulator of calcium-mediated hormone and neurotransmitter exocytosis. Defects in Rab3-GAP1 are the cause of Warburg micro syndrome 1 (WARBM1) a disorder characterized by severe developmental abnormalities of the eye and central nervous system.
Description (Vector)
RAB3GAP1 encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.
Gene ID
22930
Gene Name (eCommerce)
RAB3 GTPase activating protein catalytic subunit 1
Gene Name (Vector)
RAB3 GTPase activating protein catalytic subunit 1
Gene Symbol
RAB3GAP1
HGNC ID
HGNC:17063
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2808
ORF Size (bp)
2808 bp
Protein Name (eCommerce)
Rab3 GTPase-activating protein catalytic subunit
RefSeq ID
NM_012233
RefSeq Synonyms
NM_012233, NM_001172435, BC146809,
Research Areas
Brain Development,Neurobiology,Neurodevelopment,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Rab3-GAP1 is the catalytic subunit of Rab3-GAP. Rab3-GAP is a key regulator of calcium-mediated hormone and neurotransmitter exocytosis. Defects in Rab3-GAP1 are the cause of Warburg micro syndrome 1 (WARBM1) a disorder characterized by severe developmental abnormalities of the eye and central nervous system.
UniGene ID
Hs.306327
UniProt ID (eCommerce)
Q15042
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.