human FGFR1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FGFR1.
shADV-208992
Ad-h-FGFR1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FGFR1 (fibroblast growth factor receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD
Description (Vector)
FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Gene ID
2260
Gene Name (Vector)
fibroblast growth factor receptor 1
Gene Symbol
FGFR1
HGNC ID
HGNC:3688
ORF Size (aa)
2196
ORF Size (bp)
2196 bp
RefSeq ID
NM_015850
RefSeq Synonyms
NM_023110, NM_023106, NM_023105, NM_015850, NM_001174067, NM_001174066, NM_001174065, NM_001174064, NM_001174063, BC091494, BC018128, BC015035,
Species
human
UniGene ID
Hs.264887
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.