human DUSP1 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-207407
Availability:
3-5 weeks
Name:
Ad-h-DUSP1-shRNA
This is an Adenovirus expressing shRNA for silencing of Human DUSP1.
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Product Info
- Knockdown
- >50% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- DUSP1
- Gene Name
- dual specificity phosphatase 1
- Gene ID
- 1843
- Gene Synonyms
- CL100; HVH1; MKP-1; MKP1; PTPN10
- ORF Size
- 1104 bp
- RefSeq#
- NM_004417
- Gene Description
- The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
- UniGene ID
- Hs.171695
- HGNC ID
- HGNC:3064
Related Products
Product | Cat No. |
---|---|
AAV-h-DUSP1 | AAV-207407 |
AAV-m-DUSP1 | AAV-257528 |
Ad-h-DUSP1 | ADV-207407 |
Ad-m-DUSP1 | ADV-257528 |
AAV-h-DUSP1-shRNA | shAAV-207407 |
AAV-m-DUSP1-shRNA | shAAV-257528 |
Ad-m-DUSP1-shRNA | shADV-257528 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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