mouse PLEKHO1 shRNA silencing AAV

Cat. No: shAAV-268874

Availability: 4-5 weeks

Name: AAV-m-PLEKHO1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Plekho1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Plekho1
Gene Name: pleckstrin homology domain containing, family O member 1
Gene ID: 67220
Gene Synonyms: 2810052M02Rik; CKIP-1; Ckip1; JZA-20; Jza2
ORF Size: 1227 bp
RefSeq#: NM_023320
Gene Description: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
UniGene ID: Mm.458147