mouse EXO1 shRNA silencing AAV

Cat. No: shAAV-258767

Availability: 4-5 weeks

Name: AAV-m-EXO1-shRNA

This is an AAV expressing shRNA for silencing of Mouse Exo1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Exo1
Gene Name: exonuclease 1
Gene ID: 26909
Gene Synonyms: 5730442G03Rik; Msa
ORF Size: 2514 bp
RefSeq#: NM_012012
Gene Description: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
UniGene ID: Mm.283046