human ATF6B shRNA silencing AAV

Cat. No: shAAV-232464

Availability: 4-5 weeks

Name: AAV-h-ATF6B-shRNA

This is an AAV expressing shRNA for silencing of Human ATF6B.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ATF6B
Gene Name: activating transcription factor 6 beta
Gene ID: 1388
Gene Synonyms: CREB-RP; CREBL1; G13
ORF Size: 2112 bp
RefSeq#: NM_004381
Gene Description: ATF6B is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.
HGNC ID: HGNC:2349