human SPG20 shRNA silencing AAV

Cat. No: shAAV-224161

Availability: 4-5 weeks

Name: AAV-h-SPG20-shRNA

This is an AAV expressing shRNA for silencing of Human SPG20.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: SPG20
Gene Name: spastic paraplegia 20 (Troyer syndrome)
Gene ID: 23111
Gene Synonyms: SPARTIN; TAHCCP1
ORF Size: 2001 bp
RefSeq#: NM_015087
Gene Description: SPG20 encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
UniGene ID: Hs.440414
HGNC ID: HGNC:18514