human RASA3 shRNA silencing AAV

Cat. No: shAAV-220760

Availability: 4-5 weeks

Name: AAV-h-RASA3-shRNA

This is an AAV expressing shRNA for silencing of Human RASA3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RASA3
Gene Name: RAS p21 protein activator 3
Gene ID: 22821
Gene Synonyms: GAP1IP4BP; GAPIII
ORF Size: 2505 bp
RefSeq#: NM_007368
Gene Description: RASA3 is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
UniGene ID: Hs.593075
HGNC ID: HGNC:20331