human PVRL2 shRNA silencing AAV

Cat. No: shAAV-220419

Availability: 4-5 weeks

Name: AAV-h-PVRL2-shRNA

This is an AAV expressing shRNA for silencing of Human NECTIN2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NECTIN2
Gene Name: nectin cell adhesion molecule 2
Gene ID: 5819
Gene Synonyms: CD112; HVEB; PRR2; PVRL2; PVRR2
ORF Size: 1440 bp
RefSeq#: NM_002856
Gene Description: PVRL2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniGene ID: Hs.655455
HGNC ID: HGNC:9707