human PVRL2 shRNA silencing AAV

Name 
AAV-h-PVRL2-shRNA
Cat No 
shAAV-220419
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NECTIN2.

shAAV-220419
AAV-h-PVRL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NECTIN2 (nectin cell adhesion molecule 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD112; CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; HVEB; Nectin cell adhesion molecule 2; nectin-2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2; PRR2; PVRL2; PVRR2
Description (eCommerce)
Nectin-2/ CD112 is a type I membrane glycoprotein of the Immunoglobulin superfamily. It is a plasma membrane components of adherens junctions and acts as a receptor for certain mutant strains of herpes simplex virus and pseudorabies virus. Nectin-2/ CD112 is also a modulator of T-cell signaling. [taken from NCBI Entrez Gene (Gene ID: 389677)].
Description (Vector)
PVRL2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
5819
Gene Name (eCommerce)
nectin cell adhesion molecule 2
Gene Name (Vector)
nectin cell adhesion molecule 2
Gene Symbol
NECTIN2
HGNC ID
HGNC:9707
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1440
ORF Size (bp)
1440 bp
Protein Name (eCommerce)
Nectin-2
RefSeq ID
NM_002856
RefSeq Synonyms
NM_002856, NM_001042724, BC003091,
Research Areas
Cytoskeleton,Immunology
Research Areas (Faceted)
cell_biology,immunology
Species
human
Target Sentence
Nectin-2/ CD112 is a type I membrane glycoprotein of the Immunoglobulin superfamily. It is a plasma membrane components of adherens junctions and acts as a receptor for certain mutant strains of herpes simplex virus and pseudorabies virus. Nectin-2/ CD112 is also a modulator of T-cell signaling. [taken from NCBI Entrez Gene (Gene ID: 389677)].
UniGene ID
Hs.655455
UniProt ID (eCommerce)
Q92692

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.