human PTPRK shRNA silencing AAV

Cat. No: shAAV-220351

Availability: 4-5 weeks

Name: AAV-h-PTPRK-shRNA

This is an AAV expressing shRNA for silencing of Human PTPRK.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PTPRK
Gene Name: protein tyrosine phosphatase, receptor type K
Gene ID: 5796
Gene Synonyms: R-PTP-kappa
ORF Size: 4389 bp
RefSeq#: NM_002844
Gene Description: PTPRK is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation.
UniGene ID: Hs.155919
HGNC ID: HGNC:9674