human PPM1F shRNA silencing AAV

Cat. No: shAAV-219580

Availability: 4-5 weeks

Name: AAV-h-PPM1F-shRNA

This is an AAV expressing shRNA for silencing of Human PPM1F.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PPM1F
Gene Name: protein phosphatase, Mg2+/Mn2+ dependent 1F
Gene ID: 9647
Gene Synonyms: CAMKP; CaMKPase; FEM-2; hFEM-2; POPX2
ORF Size: 1362 bp
RefSeq#: NM_014634
Gene Description: PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.
UniGene ID: Hs.112728
HGNC ID: HGNC:19388