human POLD2 shRNA silencing AAV

Cat. No: shAAV-219348

Availability: 4-5 weeks

Name: AAV-h-POLD2-shRNA

This is an AAV expressing shRNA for silencing of Human POLD2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: POLD2
Gene Name: DNA polymerase delta 2, accessory subunit
Gene ID: 5425
ORF Size: 1410 bp
RefSeq#: NM_006230
Gene Description: POLD2 encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.
UniGene ID: Hs.306791
HGNC ID: HGNC:9176