human FGFR1OP shRNA silencing AAV

Cat. No: shAAV-208993

Availability: 4-5 weeks

Name: AAV-h-FGFR1OP-shRNA

This is an AAV expressing shRNA for silencing of Human FGFR1OP.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: FGFR1OP
Gene Name: FGFR1 oncogene partner
Gene ID: 11116
Gene Synonyms: FOP
ORF Size: 1140 bp
RefSeq#: NM_007045
Gene Description: FGFR1OP encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FGFR1OP is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.
UniGene ID: Hs.487175
HGNC ID: HGNC:17012