human EED shRNA silencing AAV

Name
AAV-h-EED-shRNA

Cat No
shAAV-207573

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human EED.

shAAV-207573

AAV-h-EED-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human EED (embryonic ectoderm development). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HEED; WAIT1

Description (Vector)

EED encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene ID

8726

Gene Name (Vector)

embryonic ectoderm development

Gene Symbol

EED

HGNC ID

HGNC:3188

ORF Size (aa)

1401

ORF Size (bp)

1401 bp

RefSeq ID

NM_003797

RefSeq Synonyms

NM_152991, NM_003797, NM_001330334, NM_001308007, BC068995,

Species

human

UniGene ID

Hs.503510

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.