Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
Seki T, etc
Nature Communications,
2016
Cold- and ß3-adrenoceptor agonist-induced sympathetic activation leads to angiogenesis and UCP1-dependent thermogenesis in mouse brown and white adipose tissues. Here we show that endothelial production of PDGF-CC during white adipose tissue (WAT) angiogenesis regulates WAT browning. We find that genetic deletion of endothelial VEGFR2, knockout of the Pdgf-c gene or pharmacological blockade of PDGFR-a impair the WAT-beige transition. We further show that PDGF-CC stimulation upregulates UCP1 expression and acquisition of a beige phenotype in differentiated mouse WAT-PDGFR-a(+) progenitor cells, as well as in human WAT-PDGFR-a(+) adipocytes, supporting the physiological relevance of our findings. Our data reveal a paracrine mechanism by which angiogenic endothelial cells modulate adipocyte metabolism, which may provide new targets for the treatment of obesity and related metabolic diseases.
- Journal
- Nature Communications
- Year
- 2016
- Page
- doi: 10.1038/ncomms12152
- Institute
- Karolinska Institute
Referenced Products
Product | Cat No. |
---|---|
Ad-m-PDGFC | ADV-268315 |
Ad-PDGF-B | 1422 |
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