Platelet-derived growth factor, beta polypeptide Adenovirus

Name 
Ad-PDGF-B
Cat No 
1422
Availability
Immediate
Categories
Adenovirus, Over-Expression

The term ‘platelet-derived growth factor’ (PDGF) refers to a family of disulphide-bonded dimeric isoforms that are important for growth, survival and function in several types of connective tissue cells. There are four members of the platelet-derived growth factor (PDGF) family; PDGF-A, PDGF-B, PDGF-C and PDGF-D. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-alpha and PDGFR-beta, and PDGF-mediated signaling is critical for development of many organ systems.

1422
Ad-PDGF-B

Ready-to-use Platelet-derived growth factor, beta polypeptide Adenovirus. Ad-PDGF-B, “Platelet-derived growth factor, beta polypeptide”, SIS,SSV,C-SIS,PDGF2,PDGFB adenovirus 1422

$690.00

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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV
Description (Vector)
PDGFB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Gene ID
5155
Gene Name (Vector)
platelet derived growth factor subunit B
Gene Symbol
PDGFB
HGNC ID
HGNC:8800
ORF Size (aa)
726
RefSeq ID
NM_002608
RefSeq Synonyms
NM_033016, NM_002608, BC077725, BC029822,
Species
human
UniGene ID
Hs.1976

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.