rat TFB2M shRNA silencing AAV

Cat. No: shAAV-292347

Availability: 4-5 weeks

Name: AAV-r-TFB2M-shRNA

This is an AAV expressing shRNA for silencing of Rat Tfb2m.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Tfb2m
Gene Name: transcription factor B2, mitochondrial
Gene ID: 289307
ORF Size: 1194 bp
RefSeq#: NM_001008293
Gene Description: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.